Joseph Fitzmyer writes regarding Genesis 3:15:
“Moreover, this verse does not mention משיח [Messiah], or even have a hidden reference to a coming Messiah, despite the later interpretations often given to it in both the Jewish and Christian tradition” (Joseph A. Fitzmyer, The One Who Is to Come [Grand Rapids: Eerdmans, 2007], 28).
The language and imagery of Genesis 3:15 is reused all across the Old Testament and into the New. Further, the blessings of Genesis 12:1-3 are the direct answer to the curses of Genesis 3:14-19, and the Balaam oracles in Numbers 22-24 connect Genesis 3:15 to Genesis 12:1-3 and Genesis 49:8-12, so that we see that within the Pentateuch itself Genesis 3:15 exercises a profound influence on the gathering lines of promise. This is picked up in the Prophets and the Writings and rightly understood by, among others, the Apostle Paul, who explains that the blessing of Abraham has come to the Gentiles in Christ Jesus (Gal 3:14, cf. 3:16).
For more detail, see these two essays:
“The Skull Crushing Seed of the Woman: Inner-Biblical Interpretation of Genesis 3:15,” The Southern Baptist Journal of Theology 10.2 (2006), 30–54.
“The Seed of the Woman and the Blessing of Abraham,” Tyndale Bulletin 58.2 (2007), 253–73.